Our Research

Knoepfler Lab Knoepfler Lab Knoepfler Lab Knoepfler Lab Knoepfler Lab
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The Knoepfler Lab is interested in epigenetics and chromatin, and the cellular machinery that regulates these states normally in stem cells and aberrantly in cancer, particularly pediatric brain tumors, as well as during faulty brain developing such as occurs with microcephaly. There are many, exciting open questions in these areas of research. For instance, what are the shared and distinct molecular events in normal and cancer stem cells? Do some of these same molecules impact brain growth in microcephaly?

We use cutting edge molecular, cellular and developmental biology methods as well as genomic and gene editing technologies to attack these questions. We are particularly interested now in the roles that the MYC family, DPPA4, and the histone variant H3.3 in stem cells and cancer. How do these factors link together the epigenome to cellular behaviors and tissue growth? The MYC family also is required for normal brain growth and MYCN is mutated in a human microcephaly syndrome.

Our big picture goal is to impact human health through discoveries in development, cancer and stem cell biology.

Join us! We are currently as of 2018 looking for a talented postdoctoral fellow to join our team, and we are always recruiting new graduate and undergraduate students as well.