I am interested in exploring questions related to genetic and epigenetic elements of stem cell programming. For example, how does this programming impact normal embryogenesis? How do disruptions of this programming contribute to tumorigenesis and will this knowledge help us to devise new treatments for cancer? Can a better understanding of how stem cell biology is normally controlled help us to get closer to using stem cells therapeutically for regenerative medicine in humans?
We are particularly interested in the Myc family of proto-oncogenes and their influence on both stem as well as tumor cell epigenetic programming.
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John Riggs, Natasha Varlakhanova, Alice Wey, Marnie Morales, Jessica Lemen, Rebecca Cotterman, Paul Knoepfler
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