Paul Knoepfler, Ph.D. is an Assistant Investigator and Member of the Institute for Pediatric Regenerative Medicine, a collaborative initiative of Shriners Hospitals for Children and The University of California Davis School of Medicine, where he is also an Assistant Professor of Cell Biology and Human Anatomy.
Education/Training B.A. English Literature Reed College 1989 Ph.D. Molecular Pathology UC San Diego 1998 Mark Kamps Lab
Post-Doctoral Fellowship 1998-2006 Robert Eisenman Lab Fred Hutchinson Cancer Center
Lucille P. Markey Graduate Fellowship 1993-1998 Jane Coffin Childs Fellowship 1998-2001 LLS Special Fellowship 2002-2005 Howard Temin Award, NCI 2005-present
Knoepfler
PS
and Bush KM. Software for the efficient management of mouse colonies. Dis Model
Mech.2010 Jan-Feb;3(1-2):9-10.
Chen D, Pacal M,
Wenzel P, Knoepfler PS, Leone G, and
Bremner R. E2F-dependent division and E2F-independent survival in the
developing retina. 2009
462(7275):925-9.
Varlakhanova, NV, and Knoepfler PS. Acting locally and
globally: Mycs ever-expanding roles on chromatin. Cancer Research 2009 69:7487-90.
Cotterman R and Knoepfler
PS. N-Myc regulates expression of pluripotency genes in neuroblastoma
including lif, klf2, klf4, and lin28b. PLoS
One 2009 4(6):
e5799.
Knoepfler PS.Deconstructing stem cell
tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells
2009. 27(5): 1050-1056.
Knoepfler PS. Journal Club. A cell biologist looks at the risk and
promise of a new insight into stem cells and cancer. Nature 2009.
457(228):361.
Knoepfler PS. Why Myc? An unexpected ingredient in the stem cell
cocktail. Cell Stem Cell. 2008.
2(1):18-21
Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Wey A,Knoepfler
PS, Eisenman RN, Roussel MF, and Dyer, MA. N-Myc coordinates retinal growth
with eye size during mouse development. Genes
and Development 2008. 22(2): 179-93.
Knoepfler PS. Stem cells on the brain. Arch Neurology 2008. 65(3): 311-315.
Cotterman R,
Jin VX, Krig SR, Lemen JM, Wey A, Farnham PJ, and Knoepfler PS. N-Myc regulates a widespread euchromatic program in
the human genome partially independent of its role as a classical transcription
factor. Cancer Research 2008. 68(23):
9654-9662.
Laurenti E,Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald R,
Eisenman RN, Bernstein ID, Trumpp A. Hematopoietic stem cell function
and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 2008. 3(6): 611-624.
Ota S, Zhou ZQ, Knoepfler
PS, and Hurlin PJ. Activities of N-Myc in the developing limb link control
of skeletal size with digit separation. Development
2007.134(8):1583-92.
Knoepfler PS. Myc goes global: new tricks for an old oncogene. Cancer Res 2007. 67(11):5061-3.
Habib T, Tsang M, Moreno de Alboran I, Nicks A, Park H,
Wilson L, Knoepfler PS, Andrews S,
Rawlings D, Eisenman RN, and Iritani BM. Myc Stimulates Lymphocyte Differentiation
and Amplifies Calcium Signaling. Journal
of Cell Biology. 2007, 179(4):717-31.
Okubo, T, Knoepfler PS, Eisenman RN, and Hogan, BLM. Nmyc plays an essential role during lung development as a dosage sensitive regulator of progenitor cell proliferation and differentiation. Development. 2005, 132(6):1363-74.
Swanson KA*, Knoepfler PS*, Huang, K, Kang RS, Cowley SM, Eisenman RN and Ishwar Radhakrishnan. The HBP1 and Mad1 repressors Recruit Sin3 by Binding to the PAH2 Domain with Opposite Helical Orientations. Nat. Struc. and Mol. Bio. 2004, 11(8):738-46. (*co-first authors).
Berkes CA, Bergstrom DA, Penn HP, Seaver KJ, Knoepfler PS, and Tapscott SJ. Pbx and Meis mark genes for activation by MyoD indicating a role for homeodomain genes in establishing myogenic potential. Mol. Cell. 2004, 14(4):465-77.
